Prof Ian Johnston

Professor

tel: 01334 463440
fax: 01334 463443
email: iaj@st-andrews.ac.uk
room: 1.2/3.1  (SOI)
Scottish Oceans Institute
East Sands
University of St Andrews
St Andrews
Fife
KY16 8LB
UK


General Information

Additional Information

School Positions
Chandos Professor of Physiology (1997-present)
Director, Scottish Oceans Institute (2012-present)
Director, Gatty Marine Laboratory (1985-2008)
Director of Research, School of Biology (2003-6)
Member, School of Biology Management Group (2000-2006) (2012-present)
Head of School: (Biology & Preclinical Medicine, 1987-1992; Environmental & Evolutionary Biology, 1997-1999)

External Positions
Steering Committee Member of the European Marine Biological Resource Centre (EMBRC) – an ESFRI Research Infrastructure in the preparatory phase (2011-2014)
Steering Committee Member of LIFECYCLE an EU-funded FP7 Integrated Research Project (2009-2013)
Vice-President (2005-2007) and President (2007-2009) Society for Experimental Biology
Member of the Natural Environment Research Council & Chairman, Marine Science & Technology Board (1995-2000)
Adjunct Professor, University of Nordland, Norway (2002-2011)

Honours
Elected Fellow Royal Society of Edinburgh 1987
Awarded Scientific Medal Zoological Society of London 1984

Research Group
Dr Vera Vieira-Johnston (Honorary Research Fellow)
Dr Daniel J. Macqueen (MASTS Research Fellow)
Dr Daniel Garcia de la serrana (EU-funded)
Dr Thomas Ashton (BBSRC-funded)
Clara Coll-Llado, PhD student/academic apprentice (50% with Dr David Ferrier)

Collaborators
Professor Shugo Watabe, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo 113-8657, Japan
Dr Bjarni K. Kristjánsson, Holar University College, Iceland
Dr Robert H. Devlin, Fisheries and Oceans Canada, West Vancouver, Canada
Professor Jorge Fernandes, University of Nordland, Norway
Industrial Partners
Young’s Seafood, SalmoBreed A/S, BioMar, Ewos Innovation

Research Overview

Genomic and physiological approaches are being used to investigate muscle growth and adaptation in teleost fish. Skeletal muscle fibres are produced during the embryonic, larval and adult stages of the lifecycle. The genetic mechanisms controlling the production of muscle fibres and their subsequent hypertrophy are being studied. Several novel myogenic genes have been discovered and their functions characterised using in vivo and in vitro using primary muscle cultures. Using various models involving body size evolution and temperature adaptation I have shown strong selection for fibre size optimization, with consequences for the life-time production of muscle fibres. Universal scaling laws affecting muscle dimensions and energy metabolism can therefore successfully explain variations in fibre number and fine scale evolutionary patterns of myogenesis between populations and species. Salmonid fish have undergone two whole genome duplications relative to their common ancestor with tetrapods resulting in up to 8 copies (paralogues) of some genes. The role of gene paralogues in the signaling pathways regulating growth is being studied. Other research interests include the molecular mechanisms underlying seasonal temperature acclimation in fish and the consequences for muscle power output and swimming performance. Embryonic stress in zebrafish was shown to have persistent affects on thermal acclimation and myogenesis that persisted to adulthood, even after fish were raised from hatching at a common temperature. The mechanisms are currently under investigation at the genomic, tissue and whole animal levels.

 
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Recent Publications

Holman, LE, Garcia de la Serrana, D, Onoufriou, A, Hillestad, B & Johnston, IA 2017, 'A workflow used to design low density SNP panels for parentage assignment and traceability in aquaculture species and its validation in Atlantic salmon' Aquaculture, vol 476, pp. 59-64. DOI: 10.1016/j.aquaculture.2017.04.001
Garcia de la Serrana, D, Jofre, EN, Martin, SAM, Johnston, IA & Macqueen, DJ 2017, 'Divergent regulation of insulin-like growth factor binding protein genes in cultured Atlantic salmon myotubes under different models of catabolism and anabolism' General and Comparative Endocrinology, vol 247, pp. 53-65. DOI: 10.1016/j.ygcen.2017.01.017
Garcia de la Serrana, D, Mareco, EA, Vieira, VLA, Power, DM & Johnston, IA 2016, 'Comparison of the transcriptional responses of skeletal muscle and bone to a flooding dose of leucine in the gilthead sea bream (Sparus aurata)' Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, vol 199, pp. 50-57. DOI: 10.1016/j.cbpb.2016.02.003
Garcia de la Serrana Castillo, D, Devlin, R & Johnston, IA 2015, 'RNAseq analysis of fast skeletal muscle in restriction-fed transgenic coho salmon (Oncorhynchus kisutch): an experimental model uncoupling the growth hormone and nutritional signals regulating growth' BMC Genomics, vol 16, no. 15, 564. DOI: 10.1186/s12864-015-1782-z
Salmerón, C, Navarro, I, Johnston, IA, Gutiérrez, J & Capilla, E 2015, 'Characterisation and expression analysis of cathepsins and ubiquitin-proteasome genes in gilthead sea bream (Sparus aurata) skeletal muscle' BMC Research Notes, vol 8, no. 149. DOI: 10.1186/s13104-015-1121-0
Mareco, EA, Garcia de la Serrana Castillo, D, Johnston, IA & Dal-Pai-Silva, M 2015, 'Characterization of the transcriptome of fast and slow muscle myotomal fibres in the pacu (Piaractus mesopotamicus)' BMC Genomics, vol 16, 182. DOI: 10.1186/s12864-015-1423-6
Johnston, IA, Garcia de la Serrana Castillo, D & Devlin, RH 2014, 'Muscle fibre size optimisation provides flexibility for energy budgeting in calorie-restricted coho salmon transgenic for growth hormone' Journal of Experimental Biology, vol 217, no. 19, pp. 3392-3395. DOI: 10.1242/jeb.107664
Mommens, M, Fernandes, JMO, Tollefsen, KE, Johnston, IA & Babiak, I 2014, 'Profiling of the embryonic Atlantic halibut (Hippoglossus hippoglossus L.) transcriptome reveals maternal transcripts as potential markers of embryo quality' BMC Genomics, vol 15, 829. DOI: 10.1186/1471-2164-15-829
Macqueen, DJ, Garcia de la Serrana Castillo, D & Johnston, IA 2014, 'Cardiac myoglobin deficit has evolved repeatedly in teleost fishes' Biology Letters, vol 10, no. 6, 20140225. DOI: 10.1098/rsbl.2014.0225
Garcia de la Serrana, D, Mareco, EA & Johnston, IA 2014, 'Systematic variation in the pattern of gene paralog retention between the teleost superorders Ostariophysi and Acanthopterygii' Genome Biology and Evolution, vol 6, no. 4, pp. 981-7. DOI: 10.1093/gbe/evu074
MacQueen, DJ & Johnston, IA 2014, 'A well-constrained estimate for the timing of the salmonid whole genome duplication reveals major decoupling from species diversification' Proceedings of the Royal Society B: Biological Sciences, vol 281, no. 1778, 20132881. DOI: 10.1098/rspb.2013.2881
Garcia de la Serrana, D, Codina, M, Capilla, E, Jimenez-Amilburu, V, Navarro, I, Du, S-J, Johnston, IA & Gutierrez, J 2014, 'Characterisation and expression of myogenesis regulatory factors during in vitro myoblast development and in vivo fasting in the gilthead sea bream (Sparus aurata)' Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 167, pp. 90-99. DOI: 10.1016/j.cbpa.2013.10.020
Salmeron, C, Garcia de la Serrana Castillo, D, Jimenez-Amilburu, V, Fontanillas, R, Navarro, I, Johnston, IA, Gutierrez, J & Capilla, E 2013, 'Characterisation and expression of calpain family members in relation to nutritional status, diet composition and flesh texture in gilthead sea bream (Sparus aurata)' PLoS One, vol 8, no. 9, e75349. DOI: 10.1371/journal.pone.0075349
Garcia de la Serrana Castillo, D & Johnston, IA 2013, 'Expression of heat shock protein (Hsp90) paralogues is regulated by amino acids in skeletal muscle of Atlantic salmon' PLoS One, vol 8, no. 9, e74295. DOI: 10.1371/journal.pone.0074295
Valente, LMP, Moutou, KA, Conceicao, LEC, Engrola, S, Fernandes, JMO & Johnston, IA 2013, 'What determines growth potential and juvenile quality of farmed fish species?' Reviews in Aquaculture, vol 5, no. Supp 1, pp. S168-S193. DOI: 10.1111/raq.12020
MacQueen, DJ, Garcia de la Serrana Castillo, D & Johnston, IA 2013, 'Evolution of ancient functions in the vertebrate insulin-like growth factor system uncovered by study of duplicated salmonid fish genomes' Molecular Biology and Evolution, vol 30, no. 5, pp. 1060-1076. DOI: 10.1093/molbev/mst017
Valente, LMP, Bower, NI & Johnston, IA 2012, 'Postprandial expression of growth-related genes in Atlantic salmon (Salmo salar L.) juveniles fasted for 1 week and fed a single meal to satiation' British Journal of Nutrition, vol 108, no. 12, pp. 2148-2157. DOI: 10.1017/S0007114512000396
Garcia de la Serrana Castillo, D, Vieira-Johnston, VLA, Andree, KB, Darias, M, Estévez, A, Gisbert, E & Johnston, IA 2012, 'Development temperature has persistent effects on muscle growth responses in gilthead sea bream' PLoS One, vol 7, no. 12, e51884. DOI: 10.1371/journal.pone.0051884
Johnston, IA, Kristjansson, BK, Paxton, CGM, Vieira-Johnston, VLA, MacQueen, DJ & Bell, MA 2012, 'Universal scaling rules predict evolutionary patterns of myogenesis in species with indeterminate growth' Proceedings of the Royal Society B: Biological Sciences, vol 279, no. 1736, pp. 2255-2261. DOI: 10.1098/rspb.2011.2536
Garcia de la Serrana Castillo, D, Estevez, A, Andree, K & Johnston, IA 2012, 'Fast skeletal muscle transcriptome of the Gilthead sea bream (Sparus aurata) determined by next generation sequencing' BMC Genomics, vol 13, 181. DOI: 10.1186/1471-2164-13-181
Amaral, IPG & Johnston, IA 2012, 'Circadian expression of clock and putative clock-controlled genes in skeletal muscle of the zebrafish' American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, vol 302, no. 1, pp. R193-R206. DOI: 10.1152/ajpregu.00367.2011
Scott, GR & Johnston, IA 2012, 'Temperature during embryonic development has persistent effects on thermal acclimation capacity in zebrafish' Proceedings of the National Academy of Sciences of the United States of America, vol 109, no. 35, pp. 14247-14252. DOI: 10.1073/pnas.1205012109
Johnston, IA, Bower, NI & Macqueen, DJ 2011, 'Growth and the regulation of myotomal muscle mass in teleost fish' Journal of Experimental Biology, vol 214, no. 10, pp. 1617-1628. DOI: 10.1242/jeb.038620
Amaral, IPGD & Johnston, IA 2011, 'Insulin-like growth factor (IGF) signalling and genome-wide transcriptional regulation in fast muscle of zebrafish following a single-satiating meal' Journal of Experimental Biology, vol 214, pp. 2125-2139. DOI: 10.1242/​jeb.053298
MacQueen, DJ, Kristjánsson, BK, Paxton, CGM, Vieira-Johnston, VLA & Johnston, IA 2011, 'The parallel evolution of dwarfism in Arctic charr is accompanied by adaptive divergence in mTOR-pathway gene expression' Molecular Ecology, vol 20, no. 15, pp. 3167-3184. DOI: 10.1111/j.1365-294X.2011.05172.x
Bower, NI & Johnston, IA 2010, 'Targeted rapid amplification of cDNA ends (T-RACE)-an improved RACE reaction through degradation of non-target sequences' Nucleic Acids Research, vol 38, no. 21, e194. DOI: 10.1093/nar/gkq816
Macqueen, DJ, Bower, NI & Johnston, IA 2010, 'Positioning the expanded akirin gene family of Atlantic salmon within the transcriptional networks of myogenesis' Biochemical and Biophysical Research Communications, vol 400, no. 4, pp. 599-605. DOI: 10.1016/j.bbrc.2010.08.110
Bower, NI & Johnston, IA 2010, 'Discovery and characterization of nutritionally regulated genes associated with muscle growth in Atlantic salmon' Physiological Genomics, vol 42A, no. 2, pp. 114-130. DOI: 10.1152/physiolgenomics.00065.2010
Macqueen, DJ, Delbridge, ML, Manthri, S & Johnston, IA 2010, 'A Newly Classified Vertebrate Calpain Protease, Directly Ancestral to CAPN1 and 2, Episodically Evolved a Restricted Physiological Function in Placental Mammals' Molecular Biology and Evolution, vol 27, no. 8, pp. 1886-1902. DOI: 10.1093/molbev/msq071
Bower, NI & Johnston, IA 2010, 'Transcriptional regulation of the IGF signaling pathway by amino acids and insulin-like growth factors during myogenesis in Atlantic salmon' PLoS One, vol 5, no. 6, e11100. DOI: 10.1371/journal.pone.0011100
Bower, NI & Johnston, IA 2010, 'Paralogs of Atlantic salmon myoblast determination factor genes are distinctly regulated in proliferating and differentiating myogenic cells' American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, vol 298, no. 6, pp. 1615-1626. DOI: 10.1152/ajpregu.00114.2010
Macqueen, DJ, Kristjansson, BK & Johnston, IA 2010, 'Salmonid genomes have a remarkably expanded akirin family, coexpressed with genes from conserved pathways governing skeletal muscle growth and catabolism' Physiological Genomics, vol 42, no. 1, pp. 134-148. DOI: 10.1152/physiolgenomics.00045.2010
Bower, NI, de la Serrana, DG & Johnston, IA 2010, 'Characterisation and differential regulation of MAFbx/Atrogin-1 alpha and beta transcripts in skeletal muscle of Atlantic salmon (Salmo salar)' Biochemical and Biophysical Research Communications, vol 396, no. 2, pp. 265-271. DOI: 10.1016/j.bbrc.2010.04.076
Ashton, TJ, Michie, I & Johnston, IA 2010, 'A Novel Tensile Test Method to Assess Texture and Gaping in Salmon Fillets' Journal of Food Science, vol 75, no. 4, pp. 182-190. DOI: 10.1111/j.1750-3841.2010.01586.x
Macqueen, DJ, Meischke, L, Manthri, S, Anwar, A, Solberg, C & Johnston, IA 2010, 'Characterisation of capn1, capn2-like, capn3 and capn11 genes in Atlantic halibut (Hippoglossus hippoglossus L.): Transcriptional regulation across tissues and in skeletal muscle at distinct nutritional states' Gene, vol 453, no. 1-2, pp. 45-58. DOI: 10.1016/j.gene.2010.01.002
Andersen, O, Torgersen, JS, Pagander, HH, Magnesen, T & Johnston, IA 2009, 'Gene expression analyses of essential catch factors in the smooth and striated adductor muscles of larval, juvenile and adult great scallop (Pecten maximus)' Journal of muscle research and cell motility, vol 30, no. 5-6, pp. 233-242. DOI: 10.1007/s10974-009-9192-y
Bower, NI, Taylor, RG & Johnston, IA 2009, 'Phasing of muscle gene expression with fasting-induced recovery growth in Atlantic salmon' Frontiers in Zoology, vol 6, 18. DOI: 10.1186/1742-9994-6-18
Bower, NI & Johnston, IA 2009, 'Selection of reference genes for expression studies with fish myogenic cell cultures' BMC Molecular Biology, vol 10, 80, pp. -. DOI: 10.1186/1471-2199-10-80
Johnston, IA, Lee, H-T, MacQueen, DJ, Paranthaman, K, Kawashima , C, Kinghorn, JR & Dalmay , T 2009, 'Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes.' Journal of Experimental Biology, vol 212, pp. 1781-1793. DOI: 10.1242/jeb.029918
Macqueen, DJ & Johnston, IA 2009, 'Evolution of the multifaceted eukaryotic akirin gene family' BMC Evolutionary Biology, vol 9, 34. DOI: 10.1186/1471-2148-9-34
Johnston, IA, Fernandes, JMO, Solberg, C & Johnston, IA 2009, 'Expression of growth-related genes in muscle during fasting and refeeding of juvenile Atlantic halibut, Hippoglossus hippoglossus L.' Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, vol 152, no. 1, pp. 47-53. DOI: 10.1016/j.cbpb.2008.09.083
Bower, NI, Li, X, Taylor, R & Johnston, IA 2008, 'Switching to fast growth: the insulin-like growth factor (IGF) system in skeletal muscle of Atlantic salmon.' Journal of Experimental Biology, vol 211, no. 24, pp. 3859-3870. DOI: 10.1242/jeb.024117
Johnston, IA & Johnston, IA 2008, 'Effect of natural selection on the duplicated lysyl oxidase gene in Atlantic salmon.' Genetica, vol 134, pp. 325-334. DOI: 10.1007/s10709-008-9240-3
Johnston, IA, Solberg, C & Johnston, IA 2008, 'Activity of Aspargate (Cathepsin D), Cysteine Proteases (Cathepsins B, B + L, and H), and Matrix Metallopeptidase (Collagenase) and their influence on protein and water-holding capacity of muscle in commercially farmed Atlantic halibut (Hippoglossus hippoglossuss L.).' Journal of Agricultural and Food Chemistry, vol 56, pp. 5953-5959. DOI: 10.1021/jf801215b
Johnston, IA, Amaral, IPG & Vleira, VLA 2008, 'Intra-specific variation in muscle fibre phenotype' Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 150. DOI: 10.1016/j.cbpa.2008.04.582
Hagen, O, Vieira-Johnston, VLA, Solberg, C & Johnston, IA 2008, 'Myotube production in fast myotomal muscle is switched-off at shorter body lengths in male than female Atlantic halibut Hippoglossus hippoglossus (L.) resulting in a lower final fibre number' Journal of Fish Biology, vol 73, no. 1, pp. 139-152. DOI: 10.1111/j.1095-8649.2008.01917.x
MacQueen, DJ, Paxton, CGM & Johnston, IA 2008, 'Temperature until the 'eyed stage' of embryogenesis programmes the growth trajectory and muscle phenotype of adult Atlantic salmon.' Biology Letters, vol 4, pp. 294.
Johnston, IA, Robb, DHF, Olsen, T, Melstveit, L, Paxton, CGM & Johnston, IA 2008, 'Temperature until the ‘eyed stage’ of embryogenesis programmes the growth trajectory and muscle phenotype of adult Atlantic salmon.' Biology Letters, vol 4, pp. 294-298. DOI: 10.1098/rsbl.2007.0620
Fernandes, J, Macqueen, DJ, Lee, H-T & Johnston, IA 2008, 'Genomic, evolutionary, and expression analyses of cee, an ancient gene involved in normal growth and development.' Genomics, vol 91, no. 4, pp. 315-325. DOI: 10.1016/j.ygeno.2007.10.017
Macqueen, DJ & Johnston, IA 2008, 'An update on MyoD evolution in teleosts and a proposed consensus nomenclature to accommodate the tetraploidization of different vertebrate genomes' PLoS One, vol 3, no. 2, e1567. DOI: 10.1371/journal.pone.0001567
Johnston, IA & MacQueen, DJ 2008, 'Evolution of follistatin in teleosts revealed through phylogenetic, genomic and expression analyses' Development Genes and Evolution, vol 218, no. 1, pp. 1-14. DOI: 10.1007/s00427-007-0194-8
Johnston, IA, MacQueen, DJ & Watabe, S 2008, Molecular biotechnology of development and growth in fish muscle. in K Tsukamoto, T Kawamura, T Takeuchi, TD Beard, Jr & MJ Kaiser (eds), Fisheries for Global Welfare and Environment: Memorial book of the 5th World Fisheries Congress 2008. Terrapub, pp. 241-262.
Johnston, IA & Andersen, O 2008, 'Number of muscle fibres in adult Atlantic cod varies with temperature during embryonic development and pantophysin (PanI) genotype.' Aquatic Biology, vol 4, pp. 167-173. DOI: 10.3354/ab00101
Johnston, IA 2008, The biological basis of variability in the texture of fish flesh. in T Børresen (ed.), Improving Seafood Products for the Consumer. CRC Press, pp. 465-489.
Johnston, IA, Condon, CHL & Johnston, IA 2007, 'Consequences of thermal acclimation for the mating behaviour and swimming performance of female mosquito fish.' Philosophical Transactions of the Royal Society. B, Biological Sciences, vol 362, pp. 2131-2139. DOI: 10.1098/rstb.2007.2106
Johnston, IA, MacKenzie, MG, Kinghorn, JR & Johnston, IA 2007, 'FoxK1splice variants show developmental stage-specific plasticity of expression with temperature in the tiger pufferfish.' Journal of Experimental Biology, vol 210, pp. 3461 - 3472. DOI: 10.1242/jeb.009183
Johnston, IA, Robb, D & Johnston, IA 2007, 'Temperature influences the co-ordinated expression of myogenic regulatory factors during embryonic embryogenesis in Atlantic salmon (Salmo salar L.).' Journal of Experimental Biology, vol 210, pp. 2781 - 2794. DOI: 10.1242/jeb.006981
MacQueen, DJ, Robb, D & Johnston, IA 2007, 'Temperature influences the coordinated expression of myogenic regulatory factors during embryonic myogenesis in Atlantic salmon (Salmo salar L.).' Journal of Experimental Biology, vol 210, pp. 2781-2794.
Johnston, IA, Solberg, C, Sirnes, E & Johnston, IA 2007, 'Biochemical and structural factors contributing to seasonal variation in the texture of farmed halibut (Hippoglossus hippoglossus L.) flesh.' Journal of Agricultural and Food Chemistry, vol 55, pp. 5803-5808. DOI: 10.1021/jf063614h
Wilson, RS, Hammill, E & Johnston, IA 2007, 'Competition moderates the benefits of thermal acclimation to reproductive performance in male eastern mosquitofish.' Proceedings of the Royal Society of London Series B: Biological Sciences, vol 274, no. 1614, pp. 1199-1204. DOI: 10.1098/rspb.2006.0401
Johnston, IA, Li, XJ, Bickerdike, R, Dingwall, A, Nickell, D, Alderson, R & Campbell, P 2007, 'Fast growth was not associated with an increased incidence of soft flesh and gaping in two strains of Atlantic salmon (Salmo salar) grown under different environmental conditions.' Aquaculture, vol 265, pp. 148-155. DOI: 10.1016/j.aquaculture.2007.01.045
Fernandes, JMO, Kinghorn, JR & Johnston, IA 2007, 'Differential regulation of multiple alternatively spliced transcripts of MyoD' Gene, vol 391, no. 1-2, pp. 178-185. DOI: 10.1016/j.gene.2006.12.015
Fernandes, J, MacKenzie, M, Kinghorn, J & Johnston, I 2007, 'Differential expression of three FoxK1 splice variants in relation to embryonic temperature in the tiger pufferfish' Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 146. DOI: 10.1016/j.cbpa.2007.01.532
Fernandes, J, Macqueen, D & Johnston, I 2007, 'Phylogeny and evolution of cee, an ancient gene of unknown function' Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 146. DOI: 10.1016/j.cbpa.2007.01.434
Macqueen, D, Fernandes, J & Johnston, I 2007, 'Characterization and expression of cee, a highly conserved and novel gene of unknown function' Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 146. DOI: 10.1016/j.cbpa.2007.01.422
Hagen, O, Vieira, V, Johnston, I & Solberg, C 2007, 'Sexual dimorphism of muscle growth in a large flattish, the Atlantic halibut (Hippoglossus hippoglossus L.)' Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 146. DOI: 10.1016/j.cbpa.2007.01.411
Vieira, V, Johnston, I & Norris, A 2007, 'Genetic variability and heritability of maximum fibre number in Atlantic salmon (Salmo salar L.)' Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 146. DOI: 10.1016/j.cbpa.2007.01.407
Macqueen, D & Johnston, I 2007, 'The transcriptional networks regulating myogenesis in Atlantic salmon (Salmo salar L.) and the effect of embryonic temperature' Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 146. DOI: 10.1016/j.cbpa.2007.01.394
Fernandes, JMO, Kinghorn, JR & Johnston, IA 2007, 'Characterization of two paralogous muscleblind-like genes from the tiger pufferfish (Takifugu rubripes)' Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, vol 146, no. 2, pp. 180-186. DOI: 10.1016/j.cbpb.2006.10.100
Li, XJ, Bickerdike, R, Nickell, D, Campbell, P, Dingwall, A & Johnston, IA 2007, 'Investigations on the effects of growth rate and dietary vitamin C on skeletal muscle collagen and hydroxylysyl pyridinoline cross-link concentration in farmed Atlantic salmon (Salmo salar).' Journal of Agricultural and Food Chemistry, vol 55, no. 2, pp. 510-515. DOI: 10.1021/jf062251i
Bai, J, Solberg, C, Fernandes, JMO & Johnston, IA 2007, 'Profiling of maternal and developmental-stage specific mRNA transcripts in Atlantic halibut Hippoglossus hippoglossus.' Gene, vol 386, pp. 202-210. DOI: 10.1016/j.gene.2006.09.012
Vicira, VLA, Norris, A & Johnston, IA 2007, 'Heritability of fibre number and size parameters and their genetic relationship to flesh quality traits in Atlantic salmon (Salmo salar L.)' Aquaculture, vol 272. DOI: 10.1016/j.aquaculture.2007.08.028
Johnston, IA, Norris, A & Johnston, IA 2007, 'Heritability of fibre number and size parameters and their genetic relationship to flesh quality traits in Atlantic salmon (Salmo salar L.) flesh.' Aquaculture, vol 272, pp. 100-109.
Johnston, IA, Abercromby, M & Andersen, O 2006, 'Muscle fibre number varies with haemoglobin phenotype in Atlantic cod as predicted by the optimal fibre number hypothesis' Biology Letters, vol 2, no. 4, pp. 590-592. DOI: 10.1098/rsbl.2006.0500
Hagen, O, Solberg, C & Johnston, IA 2006, 'Sexual dimorphism of fast muscle fibre recruitment in farmed Atlantic halibut (Hippoglossus hippoglossua L.).' Aquaculture, vol 261, pp. 1222-1229. DOI: 10.1016/j.aquaculture.2006.09.026
Consuegra, S & Johnston, IA 2006, 'Polymorphism of the lysyl oxidase gene in relation to muscle collagen cross-link concentration in Atlantic salmon.' Aquaculture Research, vol 37, pp. 1699-1702. DOI: 10.1111/j.1365-2109.2006.01609.x
Macqueen, DJ & Johnston, IA 2006, 'A novel salmonid myoD gene is distinctly regulated during development and probably arose by duplication after the genome tetraploidization (vol 580, pg 4996, 2006)' FEBS Letters, vol 580, pp. 6286-6287. DOI: 10.1016/j.febslet.2006.10.032
Sibthorpe, D, Sturlaugsdottir, MD, Kristjansson, BJ, Thorarensen, H, Skulason, S & Johnston, IA 2006, 'Characterisation and expression of the paired box protein 7 (Pax7) gene in polymorphic Arctic charr (Salvelinus alpinus).' Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, vol 145, pp. 371-383. DOI: 10.1016/j.cbpb.2006.08.013
Martin, CI & Johnston, IA 2006, 'Endurance exercise training in common carp Cyprinus carpio L. induces proliferation of myonuclei in fast muscle fibres and slow muscle fibre hypertrophy.' Journal of Fish Biology, vol 69, pp. 1221-1227. DOI: 10.1111/j.1095-8649.2006.01141.x
MacQueen, D & Johnston, IA 2006, 'A novel salmonid myoD gene is distinctly regulated during development and probably arose by duplication after the genome tetraploidization.' FEBS Letters, vol 580, pp. 4996-5002. DOI: 10.1016/j.febslet.2006.08.016
Johnston, IA, Li, X, Vieira, VLA, Nickell, D, Dingwall, A, Alderson, R, Campbell, P & Bickerdike, R 2006, 'Muscle and flesh quality traiys in wild and farmed Atlantic salmon' Aquaculture, vol 256, pp. 323-336. DOI: 10.1016/j.aquaculture.2006.02.048
Johnston, IA 2006, 'Environment and plasticity of myogenesis in teleost fish' Journal of Experimental Biology, vol 209, pp. 2249-2264. DOI: 10.1242/jeb.02153
Gotensparre, SM, Anderssen, E, Wargelius, A, Hansen, T & Johnston, IA 2006, 'Insight into the complex genetic network of tetraploid Atlantic salmon (Salmo salar L.): Description of multiple novel Pax -7 splice variants' Gene, vol 373, pp. 8-15. DOI: 10.1016/j.gene.2005.12.026
Pagander, H, Strand, O, Magnesen, T, Johnston, IA & Andersen, O 2006, 'Great scallop myostatin - The role as a negative muscle growth regulator also in invertebrates?' Journal of Shellfish Research, vol 25, pp. 298-299.
Watabe, S, Johnston, IA & Elgar, G 2006, 'International symposium on functional genomics of pufferfish: Recent advances and perspective - The University of Tokyo, Yayoi Auditorium, Tokyo, Japan, 3rd-6th Nov 2004' Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, vol 1, pp. 45. DOI: 10.1016/j.cbd.2005.12.002
Fernandes, JMO, MacKenzie, MG, Wright, PA, Steele, SL, Suzuki, Y, Kinghorn, JR & Johnston, IA 2006, 'Myogenin in model pufferfish species: Comparative genomic analysis and thermal plasticity of expression during early development' Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, vol 1, no. 1, pp. 35-45. DOI: 10.1016/j.cbd.2005.09.003
Nihei, Y, Kobiyama, A, Ikeda, D, Ono, Y, Ohara, S, Cole, NJ, Johnston, IA & Wantabe, S 2006, 'Molecular cloning and mRNA expression analysis of carp embryonic, slow and cardiac myosin heavy chain isoforms' Journal of Experimental Biology, vol 209, pp. 188-198. DOI: 10.1242/jeb.01978
Johnston, IA & Wilson, RS 2006, Temperature-induced developmental plasticity in ectotherms. in SJ Warburton, WW Burggren, B Pelster, CL Reiber & J Spicer (eds), Comparative developmental physiology: contributions, tools, and trends . Oxford University Press, pp. 124-138.
Johnston, IA, Abercromby, M & Andersen, O 2005, 'Loss of muscle fibres in a landlocked dwarf Atlantic salmon population' Biology Letters, vol 1, no. 4, pp. 419-422. DOI: 10.1098/rsbl.2005.0377
Fernandes, DA, Calvo, J & Johnston, IA 2005, 'Muscle growth in Antarctic and Sub-Antarctic notothenioid fishes' Scientia Marina, vol 69, no. Supp 2, pp. 325-336.
Martin, CI & Johnston, IA 2005, 'The molecular regulation of exercised-induced muscle fibre hypertrophy in the common carp: Expression of MyoD, PCNA and components of the calcineurin-signalling pathway' Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, vol 142, no. 3, pp. 324-334. DOI: 10.1016/j.cbpb.2005.08.004
Xuejun, L, Bickerdike, R, Lindsay, E, Campbell, P, Nickell, D, Dingwall, A & Johnston, IA 2005, 'Hydroxylysyl pyridinoline cross-link concentration affects the textural properties of fresh and smoke Atlantic salmon (Salmo salar L.) flesh.' Journal of Agricultural and Food Chemistry, vol 53, no. 17, pp. 6844-6850. DOI: 10.1021/jf050743+
Fernandes, JMO, Mackenzie, MG, Elgar, G, Suzuki, Y, Watabe, S, Kinghorn, JR & Johnston, IA 2005, 'A genomic approach to reveal novel genes associated with myotube formation in the model teleost, Takifugu rubripes' Physiological Genomics, vol 22, no. 3, pp. 327-338. DOI: 10.1152/physiolgenomics.00087.2005
MacQueen, DJ, Robb, D & Johnston, IA 2005, 'Embryonic temperature and the expression of genes regulating myogenesis in the Atlantic salmon' Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 141.
MacKenzie, MG, Fernandes, JMO, Kinghorn, JR & Johnston, IA 2005, 'Effect of temperature on expression of myogenic genes during embryonic development in the puffer fish species Takifugu rubripes' Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 141.
Chubb, HMA, Andersen, O, Pagander, HH, Strand, O, Magnesen, T & Johnston, IA 2005, 'Temperature-related plasticity of growth in the striated adductor muscle of the king scallop Pecten maximus' Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 141.
Consuegra, S & Johnston, IA 2005, 'Effect of temperature in fish genes: genetic variation in muscle lysyl oxidase of Atlantic salmon from different latitudes' Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 141.
Fernandes, JM, MacKenzie, MG, Kinghorn, JR & Johnston, IA 2005, 'Functional genomic approaches to investigating developmental plasticity to temperature in the model pufferfish species (Takifugu rubripes)' Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 141.
Vieira, VLA, Fernandes, JMO & Johnston, IA 2005, 'Characterisation and expression of genes regulating myogenesis in Antarctic and sub-Antarctic fish' Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 141.
Wilson, RS & Johnston, IA 2005, 'Mechanisms and evolutionary significance of seasonal acclimation of locomotory performance in aquatic ectotherms' Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol 141.


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