The Arctic is experiencing unprecedented rates of environmental change and has become a crucible of multiple concurrent stressors, some of which include rapid heating and decreasing sea ice concentrations. Understanding how food webs are being reshaped over different spatial and temporal scales in response to these stressors is crucial in addressing the impacts of future change on biodiversity and ecosystem services. One of the aims of ARISE, a NERC-funded “Changing Arctic Ocean” project, is to develop a new framework to detect and attribute changes to Arctic food webs over large spatial gradients and during periods of decadal change. In order to achieve this aim, we have used a suite of approaches including: observational data, stable isotope biomarkers, telemetry and modelling. We demonstrate that two Arctic predators, the ringed and harp seal can be used as model species to detect change in food web structure in the Arctic across large spatial and temporal scales.