Profile

Dr Dave Ferrier

Dr Dave Ferrier
Reader in Biology and Deputy Director of the Scottish Oceans Institute


 

Research Overview. We aim to understand how the diversity of form in the animal kingdom evolved. The focus of our research is the connection between the evolution of animal genome organisation and development, with a particular concentration on the homeobox-containing genes. The Hox gene cluster is established as a corner-stone of Evolutionary Developmental Biology, but much about the evolution of its organisation and mode of operation remains unknown. Also the Hox cluster is not unique as a homeobox gene cluster controlling animal development, further clusters being the ParaHox and NK clusters, all of which evolved within larger arrays of homeobox genes (the Mega-cluster, Giga-cluster and Super-Hox cluster). We utilize a variety of organisms in our research (including amphioxus, sea squirts, polychaetes and priapulids), chosen from key points in the phylogeny of the animals to enable reconstruction of the ancestral conditions at major nodes in the animal kingdom; the origin of bilaterians, protostomes, deuterostomes, chordates and vertebrates, as well as the origin of the entire animal kingdom. Knowledge of such ancestors is vital in understanding subsequent diversification.

source: symbiosis

 

5 (of 5 published available) for dekf with keyword ParaHox clear keyword filter. (source: University of St Andrews PURE)
Please click title of any item for full details

Amphioxus SYCP1 David Ellard Keith Ferrier
Development Genes and Evolution 2018 vol.228 pp.13-30
The origin of the Hox/ParaHox genes, the Ghost Locus hypothesis and the complexity of the first animal David Ellard Keith Ferrier
Briefings in Functional Genomics 2016 vol.15 pp.333-341
Calcisponges have a ParaHox gene and dynamic expression of dispersed NK homeobox genes Sofia Fortunato, Marcin Adamski, Sven Leininger, Jing Liu, David Ellard Keith Ferrier, Maja Adamska
Nature 2014 vol.514 pp.620-623
Time is of the essence for ParaHox homeobox gene clustering. David Ellard Keith Ferrier
BMC Biology 2013 vol.11
Features of the ancestral bilaterian inferred from Platynereis dumerilii ParaHox genes JHL Hui, F Raible, N Korchagina, N Dray, S Samain, G Magdelenat, C Jubin, B Segurens, G Balavoine, D Arendt, David Ellard Keith Ferrier
BMC Biology 2009 vol.7

Contact

The Secretary
Scottish Oceans Institute
Institiud Chuantan na h-Alba
Gatty Marine Laboratory
East Sands St Andrews
KY16 8LB
Scotland
UK

tel: +44 (0) 1334 463472
fax: +44 (0) 1334 463443
email: soi@st-andrews.ac.uk

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